Reply: Thrombophilic screening in clinical practice should be evidence-based

Pro: Should Evidence-Based Medicine Be Used More in Clinical Practice?

When first asked to write the pro side of this debate, I found myself enthusiastically accepting. After all, what possible argument could be found against implementing a more evidence-based approach to one’s clinical practice? Perhaps because of my fervent support of doing so, I found myself having trouble approaching this article. How can one write the pro side to a debate topic when the con s...

Con: Should Evidence-Based Medicine Be Used More in Clinical Practice?

A junior resident begins treatment of an elderly woman in the Emergency Department, who complains of severe epigastric abdominal pain for the last 6 hours with associated fever and vomiting. She has a rigid abdomen with diminished bowel tones, guarding and rebound. She is requesting pain medicine, but the resident refuses to give her any medications perhaps recalling the dogmatic teaching of hi...

Genetic analysis should be included in clinical practice when screening for antithrombin deficiency.

Antithrombin (AT) deficiency increases the risk of thrombosis. Current evidence shows that some SERPINC1 mutations responsible for antithrombin deficiency often present a slightly decreased or normal activity and therefore could not be detected by functional tests. This study was designed to compare activity assays and direct genetic analyses in identifying hereditary antithrombin deficiency. I...

Dolutegravir monotherapy: when should clinical practice be clinical research?

Should Clinical Services Provided by Pharmacists be Compensated?